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The nanoparticles can either directly exhibit intrinsic immunomodulatory properties to boost antitumor immune responses or be mostly used as a platform to deliver immunostimulatory agents to various targeted cells for immunotherapy. To date, many nanoparticle-based strategies have been explored to enhance the efficacy of cancer immunotherapy.
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The recent clinical successes of cancer immunotherapy (PD-1/PD-L1 immune checkpoint blockade and chimeric antigen receptor T cell therapy) are attracting considerable interest in harnessing the immune system to fight cancer. The antitumor potency conferred by NISA highlights the significance of stimulating multiple innate immune elements in cancer immunotherapy.
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Then, effective stimulation and activation of multiple components of innate immune system, including complement, macrophages, and dendritic cells were obtained, leading to efficient antitumor effect in 4T1 breast cancer cells and orthotopic breast tumor model in mice. Resultsįc fragments of NISA can be exposed through hydrolysis of long-chain PEG 5000 by highly expressed MMP-2 in tumor microenvironment. The activation of multiple components of innate immune system, including complement and the innate cells (macrophages and dendritic cells) and the associated anticancer effect were investigated. Then, long-chain PEG 5000, which was used to shield Fc to confer nanoparticle colloidal stability, was linked to the MSN surface via matrix metalloprotease-2 (MMP-2)-cleavable peptide (GPLGIAGQC). NISA was prepared through conjugating mouse IgG3 Fc to MSN surface.
Ms office 2016 pro plus activator Activator#
Here, through conjugating multivalent Fc fragments onto the surface of mesoporous silica nanoparticles (MSN), we developed a nanoparticle-based innate immune system activator (NISA) for breast cancer immunotherapy. Strategies to stimulate innate immune effectors are attracting considerable interest in cancer therapy. Harnessing the immune system to fight cancer has led to prominent clinical successes.